Hypnal is a cocrystal containing antipyrine and
chloral. Antipyrine is an analgesic and chloral is a
hypnotic agent. It was prescribed as a
pharmaceutical as early as 1890.
The crystalline composition and unique physical
properties were recognized. "Hypnal is antipyrine
combined with one molecule of hydrated chloral."
Hypnal "...occurs In colorless octahedral crystals
or a white crystalline powder... It is soluble in 10
to 11 parts of cold water" The Journal of the
American Medical Association Vol. XLVII. No. 14.
OCTOBER 6, 1906.
"It possesses all the properties of both chloral and
antipyrin, or, in other words, both relieves pain
and produces sleep. The very nature of the
compound almost of necessity makes it a useful
remedy, since, as is known to most of the
profession, chloral in ordinary doses has little
effect upon pain, and antipyrin, while relieving
pain, rarely produces sleep." The Medical News,
Vol, LVII 1890
use as early as 1890
Renovo possesses a unique business strategy that sets it
apart from other specialty pharmaceutical companies and
presents a unique value proposition to investors and strategic
We are committed to aggressively leveraging our expertise in
solid state chemistry in order to create improvements in new
and existing drug products. Renovo identifies, characterizes
and patents cocrystals of an API and then determines the
properties of the cocrystal that can be used to generate an
Renovo offers potential partners the opportunity to apply
Renovo's cocrystal technology to APIs and projects in
development. Renovo's technology can often complement or
improve the drug formulation while supplying additional
intellectual property that can create market exclusivity.
In addition to working with APIs from external partners, Renovo
also independently identifies and investigates drug molecules
that need physical property improvement. The cocrystals are
patented and the properties are investigated in order to prepare
a licensing package for development partners. Renovo has
been granted a SBIR Phase I grant from the National Science
Foundation to develop cocrystal products.
2011 Renovo Research, LLC. All rights reserved.
cocrystals of pharmaceuticals...