Cocrystal screening, scale-up
and characterization process
Renovo's expertise and experience in cocrystal research,
combined with industry leading cocrystal screening and
characterization abilities positions Renovo as the leading
authority on the application of cocrystal technology to product
improvement strategies. Renovo is uniquely positioned to
successfully screen and identify cocrystals as well as scale
up, characterize and ascertain the utility of cocrystal systems.
The typical cocrystal development stages are:
1. Screening experiments identify the cocrystals.
2. Scale up (<1g) and characterization generates the
information necessary to file a provisional patent application.
3. Determining the physical properties and utility for the
available cocrystals results in product improvement goals.
4. Formulation and dissolution experimental results generate
data that supports the project goals. Animal bioavailability
studies can be performed at this stage to further demonstrate
proof of concept. A non-provisional patent is filed.
5. Partnering to assist in further developing the product is
common at this stage. This development may be a done in a
virtual (CRO) environment, the partner with the original API
product concept may lead further development, or the
technology may be licensed to a third party.
2011 Renovo Research, LLC. All rights reserved.
Renovo operates a laboratory facility in
Atlanta, Georgia, USA that has extensive solid
state and pharmaceutical characterization
The solid state screening platform for
identifying new salts and cocrystals is a
custom designed and manufactured parallel
array process that includes a reactor block
based system that is capable of performing
grinding or slurry conversion reactions,
evaporations, reaction crystallization
experiments, or sonicated slurry conversion.
Automated powder X-ray diffraction and
Raman spectroscopy instruments are used to
characterize the samples generated in
This cocrystal screening technology is also
available as a fee for service exclusively
through our CRO partner, Triclinic Labs.
Cocrystal screening at
cocrystals of pharmaceuticals...