Cocrystal drug delivery systems
Cocrystals are an enabling technology that is used in new or
existing drug delivery systems to create a product
improvement. In cases where the physical properties of the
API form are a limiting factor in the preferred dosage form
design, using a cocrystal with improved properties can
simplify and improve the effectiveness of the formulation
Cocrystals do not replace existing drug delivery systems, but
preferably work in parallel to improve or optimize a system
while simultaneously providing a significant additional source
of IP to protect the product from competition. Renovo has also
developed a unique supersaturating drug delivery system for
cocrystals that can be applied independently or in parallel
with other drug delivery systems.
Improved cocrystal properties can represent a significant
opportunity for creating an improved drug product, but without
a well designed drug delivery system, the potential for taking
advantage of the improved cocrystal properties and making
meaningful, improved pharmaceutical products may not be
realized in many cases.
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cocrystals of pharmaceuticals...
Cocrystals represent a significant opportunity for
companies that develop proprietary drug delivery
systems. Renovo can assist in the development
of highly effective specialty formulation platforms
that, applied to an API with appropriate
properties, can create a tremendous potential for
product improvement and product differentiation.
Some examples of formulation strategies in
which cocrystals could play a significant role:
improving solubility, supersaturating drug
delivery systems, bioavailability increase for BCS
II, buccal delivery, pulsatile delivery, combination
drug formulations, and inhalation products.
Perhaps the most exploitable property of
cocrystals is the nearly instant release that can
be obtained with highly soluble cocrystals.
Cocrystals of poorly soluble drugs can reach
high supersaturation levels within seconds.
There are many opportunities for this very
unique property such as quick dissolving strips
or other formulations that require a very fast